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Darryl Appleton, M.D.

"I have experience working with patients using IV Ketamine in the past and am excited that the FDA has now approved Esketamine in a nasal spray. I feel that this is a very exciting alternative for treatment resistant depression and it works very quickly and with our expert staff and individualized protocol we expect fantastic results."


 Meredith Chadeayne, LCSW

Meredith Chadeayne is a Florida Licensed Clinic Social Worker. Meredith will observe and monitor you during the administration period while providing therapeutic support.

We note that eskatamine has better results when a trained professional is there with you during your treatments and can provide some therapy and support during the session. This is what differentiates us from many clinics.


 Meredith graduated from Fordham University with honors. She has worked in numerous treatment facilities with numerous different modalities. Meredith is a trauma specialist who is trained in EMDR. At West Palm Hospital, she was in charge of the adolescent program with a focus on mental health. Meredith does EMDR psychotherapy and works with patients suffering from PTSD as well as other psychological conditions.


What is Eskatamine?

Eskatamine is a prescription medicine nasal spray you self-administer under the supervision of a healthcare professional and is used along with an antidepressant for treatment resistant depression in adults. A healthcare professional will monitor you for at least two hours during the observation period for possible side effects.

Eskatamine is not for use as a medicine to prevent or relieve pain (anesthetic). It is not known if Eskatamine is safe or effective as an anesthetic medicine. 

How is Eskatamine taken?

  • Eskatamine is taken twice a week for the first four weeks

  • After the first four weeks, Eskatamine is taken once a week for a month

  • After this, Eskatamine is usually taken either once a week or once every two weeks

Safety  & Tolerability

  • Eskatamine nasal spray was evaluated for safety in both short- and long-term clinical trials of adults diagnosed with treatment-resistant depression.

  • Do not take Eskatamine if you have a blood vessel disease (aneurysm), an abnormal connection between your blood vessels (arteriovenous malformation), a history of bleeding in the brain or are allergic to esketamine, ketamine or any of the ingredients in Eskatamine. Talk to your doctor to learn more.

Possible Side Effects

Serious side effects reported with Eskatamine include sedation and dissociation, and there is a risk of abuse and misuse with Eskatamine.

There’s an increased risk of suicidal thoughts and behavior with Eskatamine.

Call your doctor right away if you have new or sudden changes in mood, behavior, thoughts or feelings.

Other possible serious side effects include: temporary increased blood pressure that may last about four hours after a dose, problems with thinking clearly or bladder problems, such as a frequent or urgent need to urinate, pain when urinating or urinating frequently at night.

The most common side effects that can occur during and after taking Eskatamine include:

  • Dissociation (feeling disconnected from yourself, your thoughts, feelings, space and time)

  • Dizziness

  • Nausea

  • Sedation (sleepiness)

  • Spinning sensation

  • Reduced sense of touch and sensation

  • Anxiety

  • Lack of energy

  • Increased blood pressure

  • Vomiting

  • Feeling drunk

If these common side effects occur, they usually happen right after taking Eskatamine and go away the same day.

Because of the possibility of nausea and vomiting, you should avoid eating two hours before, and drinking liquids 30 minutes before, taking Eskatamine.


“I no longer start off each day sad and about to cry. With SPRAVATO™, I'm starting off at a place like neutral, which is, like, the best.”

Nicole P., St. Peters, Missouri

Nicole, 23, is a real patient with treatment-resistant depression and
has been compensated for her time by Janssen Pharmaceuticals, Inc.


“When you’re depressed, you forget about the little things you used to enjoy. I’m catching up on all that now.”

Robin P., Berkeley, California

Robin is a real patient with treatment-resistant depression and has
been compensated for her time by Janssen Pharmaceuticals, Inc.

Phone: (561) 450-8328
Fax: (561) 450-5817


If you or someone you know is struggling with suicidal thoughts, please contact the National Suicide Prevention Lifeline. It provides free and confidential 24/7 support for people in distress, as well as prevention and crisis resources. 1 (800) 273-TALK (8255)

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